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Common names

JWH-073, Spice

Systematic name



jwh-073 is an analgesic chemical from the naphthoylindole family that acts as a partial agonist at both the cb1 and cb2 cannabinoid receptors. it is somewhat selective for the cb1 subtype, with affinity at this subtype approximately 5x the affinity at cb2. the abbreviation jwh stands for john w. huffman, one of the inventors of the compound.


jwh-073 gained popularity in april 2009, when it was claimed by chemists at the university of freiburg to have been found in a “fertilizer” product called “forest humus”, along with another synthetic cannabinoid, cp 47,497. it was subsequently found as a chemical within the popular synthetic cannabis blend spice, which had been sold in numerous countries aroun